Eric Chou

Eric Chou

Publications

High-impact chronic pain in sickle cell disease: insights from the Pain in Sickle Cell Epidemiology Study (PiSCES)

Published in PAIN, 2024

In this study, we leveraged data previously collected in the landmark PiSCES study to examine the HICP phenotype in SCD. We proposed to compare the pain phenotype and outcomes between those with a HICP-like phenotype, hereafter referred to as the HICP group, with those who had CP but did not have HICP, hereafter referred to as the No-HICP group. We also examined the association between HRQoL outcomes and HICP status.

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Multimodal phenotyping and correlates of pain following hematopoietic cell transplant in children with sickle cell disease

Published in Pediatric Blood & Cancer, 2022

There is limited understanding of pain, psychological comorbidities associated with pain and HRQoL following transplantation for SCD. This study aimed to determine the feasibility and acceptability of collecting data on pain, patient-reported outcomes (PROs), HRQoL and experimental pain sensitivity using quantitative sensory testing (QST), and to compare these before and following HCT in patients with SCD. We hypothesized that there would be a decrease in pain burden following HCT and improvement in pain-associated psychological comorbidity.

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Designing and evaluating contextualized drug–drug interaction algorithms

Published in JAMIA Open, 2021

Alert fatigue is a common issue with off-the-shelf clinical decision support. Most warnings for drug–drug interactions (DDIs) are overridden or ignored, likely because they lack relevance to the patient’s clinical situation. Existing alerting systems for DDIs are often simplistic in nature or do not take the specific patient context into consideration, leading to overly sensitive alerts. The objective of this study is to develop, validate, and test DDI alert algorithms that take advantage of patient context available in electronic health records (EHRs) data.

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Fall Risk-Increasing Drugs, Polypharmacy, and Falls Among Low-Income Community-Dwelling Older Adults

Published in Innovation In Aging, 2021

Medication exposure is a potential risk factor for falls and subsequent death and functional decline among older adults. However, controversy remains on the best way to assess medication exposure and which approach best predicts falls. The objective of the current study was to examine the association between different measures of medication exposure and falls risk among community-dwelling older adults.

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A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: from Chemical Characterization to Clinical Studies

Published in Drug Metabolism and Disposition, 2020

There are many gaps in scientific knowledge about the clinical significance of pharmacokinetic natural product-drug interactions (NPDIs) in which the NP is the precipitant and a conventional drug is the object. The National Center for Complimentary and Integrative Health created the Center of Excellence for NPDI Research (NaPDI Center) (www.napdi.org) to provide leadership and guidance on the study of pharmacokinetic NPDIs. A key contribution of the Center is the first user-friendly online repository that stores and links pharmacokinetic NPDI data across chemical characterization, metabolomics analyses, and pharmacokinetic in vitro and clinical experiments (repo.napdi.org)…

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Developing User Personas to Aid in the Design of a User-Centered Natural Product-Drug Interaction Information Resource for Researchers

Published in American Medical Informatics Association 2018 Annual Symposium, 2018

Pharmacokinetic interactions between natural products and conventional drugs can adversely impact patient outcomes. These complex interactions present unique challenges that require clear communication to researchers. We are creating a public information portal to facilitate researchers’ access to credible evidence about these interactions. As part of a user-centered design process, three types of intended researchers were surveyed: drug-drug interaction scientists, clinical pharmacists, and drug compendium editors…

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